The Science Behind Legal Highs: How Do They Work?
- James Santana
- Mar 19
- 3 min read
As interest in legal alternatives to traditional substances grows, more people are turning to products like kratom, kava, amanita mushrooms, and hemp-derived THC. But how do these legal highs actually work in the body? Understanding the science behind them can help you make informed choices and get the most out of your experience.
Kratom: The Natural Stimulant & Relaxant
Kratom (Mitragyna speciosa) is a tropical plant native to Southeast Asia. The effects of kratom depend on the dosage and the specific alkaloids in the leaves, primarily mitragynine and 7-hydroxymitragynine. These compounds interact with the brain’s opioid receptors, but in a way that differs from traditional opioids, making kratom unique.
Low doses act as a stimulant, increasing energy, focus, and motivation.
Higher doses provide relaxation, mild euphoria, and stress relief.
Unlike opioids, kratom doesn’t cause the same level of respiratory depression, which is why many people see it as a safer alternative. At Regime Vape & Smoke, we offer premium-quality kratom strains to help you find the right balance for your lifestyle.

Kava: The Stress-Reliever Without the Hangover
Kava (Piper methysticum) is a root from the South Pacific known for its calming effects. The active compounds, called kavalactones, interact with the brain’s GABA receptors—the same system affected by alcohol and anti-anxiety medications.
Promotes relaxation without impairing mental clarity.
Helps reduce social anxiety.
Enhances mood while keeping the mind alert.
Kava is a popular alternative for those who want to unwind without the risk of a hangover or brain fog. Find high-quality kava products at Regime Vape & Smoke, where we specialize in legal highs that enhance your well-being.

Amanita Muscaria Mushrooms: Psychedelic Effects Without Psilocybin
Unlike psilocybin mushrooms, Amanita muscaria (the red-and-white “Mario” mushroom) contains muscimol and ibotenic acid, which interact with GABA receptors in the brain.
Low doses produce mild euphoria and relaxation.
Moderate doses can lead to dream-like states and altered perception.
High doses may cause deeper psychedelic experiences, though these should be approached with caution.
Amanita is gaining popularity as a legal alternative for those interested in a unique mind-expanding experience. If you're curious about trying mushroom gummies or amanita extracts, Regime Vape & Smoke carries a carefully curated selection to ensure quality and safety.

Hemp-Derived THC: The Legal Cannabis Alternative
With cannabis laws varying from state to state, hemp-derived THC products like Delta-8, Delta-10, HHC, and THCa have become go-to options for many. These cannabinoids interact with the endocannabinoid system (ECS), which regulates mood, pain, and sleep.
Delta-8 THC: Milder than Delta-9 THC, offering relaxation with reduced anxiety.
HHC (Hexahydrocannabinol): A hydrogenated form of THC, known for its smooth, balanced effects.
THCa (Tetrahydrocannabinolic Acid): The raw form of THC, which converts into Delta-9 THC when heated.
Each type of hemp-derived THC offers a slightly different experience, making it easier to find the perfect fit for your needs. At Regime Vape & Smoke, we provide top-tier THC gummies, disposable vapes, and tinctures for a clean and consistent experience.

The Bottom Line
Legal highs work by interacting with different brain receptors to create a variety of effects, from stimulation and relaxation to mood enhancement and altered perception. Whether you’re looking for stress relief, focus, or a unique mind-expanding experience, there’s a legal alternative out there for you.
Interested in trying the best legal highs? Check out our carefully curated selection at Regime Vape & Smoke, your trusted source for kratom, kava, amanita mushrooms, and hemp-derived THC products. Visit our online store today and find the perfect product for your needs!
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